GSTP1 Polymorphisms Sex-specific association with verbal intelligence in survivors of pediatric medulloblastoma

Congrats to Rella Kautiainen, the author of a recent paper looking at genetic correlates of verbal intelligence outcomes in survivors of medulloblastoma. 

Children with the same cerebellar brain tumors (medulloblastoma) and treatment (surgery, chemotherapy, and radiation), but they have substantial variability in cognitive outcomes. This variability may partially be due to treatment-related toxicity conferred by genetic risk, including polymorphisms on the GSTP1 gene. Our study found that female medulloblastoma survivors with a GSTP1 polymorphism may have increased vulnerability to deficits in core cognitive skills, IQ, and everyday functional outcomes. 

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