Publications

28. Li, H.; Shen, S.-J.; Zhu, C.-L.; Xu, H.^* “Direct Intermolecular Anti–Markovnikov Hydroazidation of Unactivated Olefins” J. Am. Chem. Soc. 2019. DOI: 10.1021/jacs.9b04381

27. Li, H.; Shen, S.-J.; Zhu, C.-L.; Xu, H.* “Enantioselective Synthesis of Oseltamivir Phosphate (Tamiflu) via the Iron-Catalyzed Stereoselective Olefin Diazidation.” J. Am. Chem. Soc. 2018. DOI: 10.1021/jacs.8b06900

26. Zhu, C.-L.; Wang, C.; Qin, Q.-X.; Yruegas, S.; Martin, C. D.; Xu, H.^* “Iron-Catalyzed Olefin Azido-Trifluoromethylation for Vicinal Trifluoromethyl Amine Synthesis” ACS Catal. 2018, 8, 5032.

25. Shen, S.-J.; Zhu, C.-L.; Lu, D.-F.; Xu, H.^* “Iron-Catalyzed Direct Olefin Diazidation via Peroxyester Activation Promoted by Nitrogen-Based Ligands” ACS Catal. 2018, 8, 4473.

24. Zhu, H.-T.; Arosio, L.; Villa, R.; Nebuloni. M.;^* Xu, H.^* “Chemical Process Safety Assessment of the Iron-Catalyzed Direct Olefin Diazidation for Expedient Synthesis of Vicinal Primary Diamines” Org. Process Res. Dev. 2017, 21, 2068.

Comments from Chemical and Engineering News: Azides safely used to synthesize diamines.

23. Lu, D.-F.; Zhu, C.-L.; Sears, J. D.; Xu, H.^{* “}Iron(II)-Catalyzed Intermolecular Aminofluorination of Unfunctionalized Olefins Using Fluoride Ion” J. Am. Chem. Soc. 2016, 138, DOI: 10.1021/jacs.6b07221

TOC aminofluorination jpeg

22. Zhu, C.-L.; Lu, D.-F.; Sears, J. D.; Jia, Z.-X.; Xu, H.^* “Practical Synthetic Procedures of the Iron-Catalyzed Intermolecular Olefin Aminohydroxylation Using Functionalized Hydroxylamines” Synthesis, 2016, DOI: 10.1055/s-0035-1562515 (Invited Practical Synthetic Procedure Contribution).

Scheme 1

21. Yuan, Y.-A.; Lu, D.-F.; Chen, Y.-R.; Xu, H.^* “Iron-Catalyzed Direct Diazidation for a Broad Range of Olefins” Angew. Chem. Int. Ed. 2015, accepted, DOI: 10.1002/anie.201507550R1

Table of Content diazidation modified for proposal

20. Zhu, C.-L.; Tian, J.-S.; Gu, Z.-Y.; Xing, G.-W.; Xu, H.^* “Iron(II)-Catalyzed Asymmetric Intramolecular Olefin Aminochlorination with Chloride Ion” Chem. Sci. 2015, 6, DOI: 10.1039/C5SC00221D

aminochlorination

19. Tian, J.-S.; Zhu, C.-L.; Chen, Y.-R.; Xu, H.^* “Iron-Catalyzed Diastereoselective Olefin Aminobromination with Bromide Ion” Synthesis 2015, DOI: 10.1055/s-0034-1378719 (Invited Special Issue Contribution: Iron in Organic Synthesis).

TOC for website

18. Lu, D. F.; Zhu, C. L.; Jia, Z. X.; Xu, H.* “Iron(II)-Catalyzed Intermolecular Amino-Oxygenation of Olefins through the N-O Bond Cleavage of Functionalized Hydroxylamines” J. Am. Chem. Soc. 2014, 136, 13186.

TOC JACS

17. Lu, D. F.; Liu, G. S.; Zhu, C. L.; Yuan, B.; Xu, H.* “Iron(II)-Catalyzed Intramolecular Olefin Aminofluorination.” Org. Lett. 2014, 16, 2912.

Scheme 1

16. Zhu, C. L.; Zhang, Y. Q.; Yuan, Y. A.; Xu, H.* “Copper-Catalyzed Aerobic C-H Trifluoromethylation of Phenanthrolines.” Synlett. 2014, 25, DOI: 10.1055/s-0034-1379319 (Invited Cluster Report: Catalysis with Sustainable Metals).

highlight Sept 20

15. Liu, G. S.; Zhang, Y. Q.; Yuan, Y. A.; Xu, H.* “Iron(II)-Catalyzed Intramolecular Aminohydroxylation of Olefin with Functionalized Hydroxylamines.” J. Am. Chem. Soc. 2013, 135, 3343

TOC revised

14. Lu, D. F.; Zhu, C. L.; Xu, H.* “Copper(I)-Catalyzed Diastereoselective Hydroxytrifluoromethylation of Dienes Accelerated by Phosphine Ligands” Chem. Sci. 2013, 4, 2478

TOC

13. Zhang, Y. Q.; Yuan, Y. A.; Liu, G. S.; Xu, H.* “Iron(II)-Catalyzed Asymmetric Intramolecular Aminohydroxylation of Indoles.” Org. Lett. 2013, 15, 3910.

TOC OL

12. Zhang, Y. Q.; Liu, J. D.; Xu, H.* “Copper(II)-Catalyzed Trifluoromethylation of N-Aryl Imines.” Org. Biomol. Chem. 2013, 11, 6242.

TOC OBC

11. Liu, G. S.; Wilkerson, P. D.; Toth, C. A.; Xu, H.* “Highly Enantioselective Cyclizations of Conjugated Trienes with Low Catalyst Loadings: A Robust Chiral NHC Enabled by Acetic Acid Cocatalyst.” Org. Lett. 2012, 14, 858.

title_updated

Postdoctoral Research

10. Xu, H.; Zhang, H.; Jacobsen, E. N. “Enantioselective Catalytic Povarov Reactions to Access Stereochemically Rich Tetrahydroquinolines. Asymmetric Catalysis of Strong Brønsted Acid-Promoted Reactions Using Chiral Ureas.” Nat. Protoc. 2014, 9, 1860.

9. Gerard, B.; O’Shea, M. W.; Donckele, E.; Kesavan, S.; Akella, L. B.; Xu, H.; Jacobsen, E. N.; Marcaurelle, L. A. “Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library.” ACS Comb. Sci. 2012, 14, 621.

8. Xu, H.; Zuend, S. J.; Woll, M. G.; Tao, Y.; Jacobsen, E. N. “Asymmetric Cooperative Catalysis of Strong Brønsted Acid-Promoted Reactions using Chiral Ureas.” Science 2010, 327, 986.