Publications

2023

Genetics re-establish the utility of 2-methylhopanes as cyanobacterial biomarkers before 750 million years ago.

Hoshino Y, Nettersheim BJ, Gold DA, Hallmann C, Vinnichenko G, van Maldegem LM, Bishop C, Brocks JJ, Gaucher EA.Nat Ecol Evol. 2023 Oct 26. doi: 10.1038/s41559-023-02223-5. Online ahead of print.PMID: 37884688

Protection of Catalytic Cofactors by Polypeptides as a Driver for the Emergence of Primordial Enzymes.

Gutierrez-Rus LI, Gamiz-Arco G, Gavira JA, Gaucher EA, Risso VA, Sanchez-Ruiz JM.Mol Biol Evol. 2023 Jun 1;40(6):msad126. doi: 10.1093/molbev/msad126.PMID: 37235753

Oral Delivery of Nanoparticles Carrying Ancestral Uricase Enzyme Protects against Hyperuricemia in Knockout Mice.

Tran L, Das S, Zhao L, Finn MG, Gaucher EA.Biomacromolecules. 2023 May 8;24(5):2003-2008. doi: 10.1021/acs.biomac.2c01388. Epub 2023 Apr 26.PMID: 37126604

2022

Johnson RJ, Sánchez-Lozada LG, Nakagawa T, Rodriguez-Iturbe B, Tolan D, Gaucher EA, Andrews P, Lanaspa MA.Obesity (Silver Spring). 2022 Oct;30(10):1917-1926. doi: 10.1002/oby.23540.PMID: 36150210 Review.

 

2021

Selberg AGA, Gaucher EA, Liberles DA.J Mol Evol. 2021 Apr;89(3):157-164. doi: 10.1007/s00239-021-09993-1. Epub 2021 Jan 24.PMID: 33486547
Fini MA, Lanaspa MA, Gaucher EA, Boutwell B, Nakagawa T, Wright RM, Sanchez-Lozada LG, Andrews P, Stenmark KR, Johnson RJ.Cancer Metab. 2021 Sep 15;9(1):32. doi: 10.1186/s40170-021-00268-3.PMID: 34526149

2020

 

Stabilization of Near-Infrared Fluorescent Proteins by Packaging in Virus-like Particles.
Das S, Zhao L, Crooke SN, Tran L, Bhattacharya S, Gaucher EA, Finn MG.Biomacromolecules. 2020 Jun 8;21(6):2432-2439. doi: 10.1021/acs.biomac.0c00362. Epub 2020 May 22.PMID: 32441521

 

Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts.

Johnson RJ, Stenvinkel P, Andrews P, Sánchez-Lozada LG, Nakagawa T, Gaucher E, Andres-Hernando A, Rodriguez-Iturbe B, Jimenez CR, Garcia G, Kang DH, Tolan DR, Lanaspa MA.J Intern Med. 2020 Mar;287(3):252-262. doi: 10.1111/joim.12993. Epub 2019 Oct 31.PMID: 31621967

2019

 

2018

 

2017

 

De novo active sites for resurrected Precambrian enzymes.

Risso VA, Martinez-Rodriguez S, Candel AM, Krüger DM, Pantoja-Uceda D, Ortega-Muñoz M, Santoyo-Gonzalez F, Gaucher EA, Kamerlin SCL, Bruix M, Gavira JA, Sanchez-Ruiz JM.Nat Commun. 2017 Jul 18;8:16113. doi: 10.1038/ncomms16113.PMID: 28719578

 

 

2016

 

2015

 

 

2014

 

 

 

 

Risso VA, Manssour-Triedo F, Delgado-Delgado A, Arco R, Barroso-delJesus A, Ingles-Prieto A, Godoy-Ruiz R, Gavira JA, Gaucher EA, Ibarra-Molero B, Sanchez-Ruiz JM.Mol Biol Evol. 2015 Feb;32(2):440-55. doi: 10.1093/molbev/msu312. Epub 2014 Nov 12.PMID: 25392342

 

2013

 

 

 

 

 

 

 

2012

 

2011

Utilizing natural diversity to evolve protein function: applications towards thermostability.
Cole MF, Gaucher EA.Curr Opin Chem Biol. 2011 Jun;15(3):399-406. doi: 10.1016/j.cbpa.2011.03.005. Epub 2011 Apr 4.PMID: 21470898

 

 

2010

Deep phylogeny–how a tree can help characterize early life on Earth.
Gaucher EA, Kratzer JT, Randall RN.Cold Spring Harb Perspect Biol. 2010 Jan;2(1):a002238. doi: 10.1101/cshperspect.a002238.PMID: 20182607

 

2009

 

Perez-Jimenez R, Li J, Kosuri P, Sanchez-Romero I, Wiita AP, Rodriguez-Larrea D, Chueca A, Holmgren A, Miranda-Vizuete A, Becker K, Cho SH, Beckwith J, Gelhaye E, Jacquot JP, Gaucher EA, Sanchez-Ruiz JM, Berne BJ, Fernandez JM.Nat Struct Mol Biol. 2009 Aug;16(8):890-6. doi: 10.1038/nsmb.1627. Epub 2009 Jul 13.PMID: 19597482

2008

 

 

2007

 

2006

 

 

 

2005

 

2004

 Cytoplasmic glycosylation of protein-hydroxyproline and its relationship to other glycosylation pathways.
West CM, Van Der Wel H, Sassi S, Gaucher EA.Biochim Biophys Acta. 2004 Jul 6;1673(1-2):29-44. doi: 10.1016/j.bbagen.2004.04.007.PMID: 15238247 Review.

Gaucher EA, Graddy LG, Li T, Simmen RC, Simmen FA, Schreiber DR, Liberles DA, Janis CM, Benner SA.BMC Biol. 2004 Aug 17;2:19. doi: 10.1186/1741-7007-2-19.PMID: 15315709

 

2003

 

 

2002

 

 

 

 

 

2001

 

 

1998

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