Featured Research
Representative Publications
A bimolecular CO prodrug strategy
“A click-and-release approach to CO prodrugs.” Chemical Communications 50, no. 100 2014: 15890-15893
Unimolecular CO prodrugs using intramolecular DAinv reaction
“Click and Release: A Chemical Strategy toward Developing Gasotransmitter Prodrugs by Using an Intramolecular Diels-Alder Reaction” Angew. Chem. Int. Ed. Engl. 2016, 55, 15846-15851.
Enrichment triggered CO release within the mitochondria
“Enrichment-triggered Prodrug Activation Demonstrated through Mitochondria-targeted Delivery of Doxorubicin and Carbon Monoxide” Nature Chem. 2018, 10, 787-794.
pH-triggered CO prodrugs based on beta elimination
“pH-sensitive Metal-free Carbon Monoxide Prodrugs with Tunable and Predictable Release Rates” Chem. Commun. 2017, 53, 9628 – 9631.
ROS-triggered CO prodrugs based on beta elimination
“Organic CO prodrugs activated by endogenous ROS” Org. Lett. 2018, 20, 8-11.
Esterase-triggered CO prodrugs
“An Esterase-activated Click and Release Approach to Metal-free CO-prodrugs” Chem. Commun. 2017, 53, 8296-8299