Video Introduction | MyNCBI Bibliography | Research Seminar Video
I. General Research Interest
- Diet and cancer
i. Cancer prevention by dietary isoprenoids via suppression of the mevalonate pathway - Alzheimer’s disease
i. Impact of isoprenoids on Alzheimer’s disease via modulation of the intermediate and end products of the mevalonate pathway - Roles of sterols and non-sterol isoprenoids in obesity and bone health
II. Current research projects
- The mevalonate-suppressive activity of specialty plant oils
III. Research skills
- Cell culture: various cancer cells, adipocytes, macrophages
- Cell cycle and apoptosis analysis
- Biochemical and molecular analysis of gene expression, e.g. PCR, Western-blot.
- In vivo cancer models
HMG CoA reductase
3-hydroxy-3-methylglutaryl coenzyme A
Isoprenoid
Lovastatin
Mevacor
Pravacor
Mevinolin
Terpene
Isoprenoid
Monoterpene
Limonene
Perillyl alcohol
Ionone
Geranylgeraniol
Tocotrienol
Farnesol
Geraniol
Carveol
Carvacrol
Cineole
Thymol
Essential oil
Caax
Farnesyl
Geranylgeranyl
Lamin
Ras
Mevalonate
Prenylation
Prenyl
Mevalonate
Mevalonic acid
Cholesterol
Sterol
Tumor
Cancer
Neoplasm
Melanoma
Chemoprevention
Cell cycle
Apoptosis
Alzheimer
Tau
Beta amyloid