Publications

Articles Published in 2024

The Role of Small Molecules Containing Fluorine Atoms in Medicine and Imaging Applications

 

Influence of structural moieties in squaraine dyes on optoacoustic signal shape and intensity

 

Articles Published in 2023

Pafolacianine, the magic wand of intraoperative imaging of folate-receptor positive ovarian cancer

 

Exploration of NIR Squaraine Contrast Agents Containing Various Heterocycles: Synthesis, Optical Properties and Applications

 

Physicochemical Descriptors in Biodistribution and Clearance of Contrast Agents

 

Synthesis, Optical Properties, and In Vivo Biodistribution Performance of Polymethine Cyanine Fluorophores

 

(Z)-3-(Dicyanomethylene)-4-((5-fluoro-3,3-dimethyl-1-(3-phenylpropyl)-3H-indol-1-ium-2-yl) methylene)-2-(((E)-5-fluoro-3,3-dimethyl-1-(3-phenylpropyl)indolin-2-ylidene)methyl) cyclobut-1-en-1-olate

 

H2S Sensors: Synthesis, Optical Properties, and Selected Biomedical Applications under Visible and NIR Light

 

Articles Published in 2022


Yokomizo, S., Henary, M., Buabeng, E. R., Fukuda, T., Monaco, H., Baek, Y., Manganiello, S., Wang, H., Kubota, J., Ulumben, A. D., Lv, X., Wang, C., Inoue, K., Fukushi, M., Kang, H., Bao, K., Kashiwagi, S., Choi, H. S., Topical pH Sensing NIR Fluorophores for Intraoperative Imaging and Surgery of Disseminated Ovarian Cancer. Adv. Sci. 2022, 9, 2201416.

T. Fukuda, S. Yokomizo, S. Casa, H. Monaco, S. Manganiello, H. Wang, X. Lv, A. D. Ulumben, C. Yang, M.-W. Kang, K. Inoue, M. Fukushi, T. Sumi, C. Wang, H. Kang, K. Bao, M. Henary, S. Kashiwagi, H. Soo Choi, Angew. Chem. Int. Ed. 2022, 61, e202117330; Angew. Chem. 2022, 134, e202117330.

Kang, H., Shamim, M., Yin, X., Adluru, E., Fukuda, T., Yokomizo, S., Chang, H., Park, S. H., Cui, Y., Moy, A. J., Kashiwagi, S., Henary, M., Choi, H. S., Tumor-Associated Immune-Cell-Mediated Tumor-Targeting Mechanism with NIR-II Fluorescence Imaging. Adv. Mater. 2022, 34, 2106500.

Tran, T.N.; Henary, M. Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents. Molecules 2022, 27, 2700.

Articles Published in 2021


St. Lorenz, A.;  Buabeng, E. R.;  Taratula, O.;  Taratula, O.; Henary, M., Near-Infrared Heptamethine Cyanine Dyes for Nanoparticle-Based Photoacoustic Imaging and Photothermal Therapy. Journal of Medicinal Chemistry 2021, 64 (12), 8798-8805.

Essam, Z. M.;  Ozmen, G. E.;  Setiawan, D.;  Hamid, R. R.;  Abd El-Aal, R. M.;  Aneja, R.;  Hamelberg, D.; Henary, M., Donor acceptor fluorophores: synthesis, optical properties, TD-DFT and cytotoxicity studies. Organic & Biomolecular Chemistry 2021, 19 (8), 1835-1846.

Lovett, W. R.;  Al Hamd, A.;  Casa, S.; Henary, M., Synthesis of pH-sensitive benzothiazole cyanine dye derivatives containing a pyridine moiety at the meso position. Dyes and Pigments 2021, 190, 109268.

Buabeng, E. R.; Henary, M., Developments of small molecules as inhibitors for carbonic anhydrase isoforms. Bioorganic & Medicinal Chemistry 2021, 39, 116140.

Ilina, K.; Henary, M., Frontispiece: Cyanine Dyes Containing Quinoline Moieties: History, Synthesis, Optical Properties, and Applications. Chemistry – A European Journal 2021, 27 (13).

Casa, S.; Henary, M., Synthesis and Applications of Selected Fluorine-Containing Fluorophores. Molecules 2021, 26 (4).

Laramie, M. D.;  Fouts, B. L.;  MacCuaig, W. M.;  Buabeng, E.;  Jones, M. A.;  Mukherjee, P.;  Behkam, B.;  McNally, L. R.; Henary, M., Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer. Scientific Reports 2021, 11 (1), 4366.

Buabeng, E. R.; Henary, M., 2-((E)-2-((E)-4-Chloro-5-(2-((E)-5-methoxy-3,3-dimethyl-1-(3-phenylpropyl)indolin-2-ylidene) ethylidene)-1,1-dimethyl-1,2,5,6-tetrahydropyridin-1-ium-3-yl)vinyl)-5-methoxy-3,3-dimethyl-1-(3-phenylpropyl)-3H-indol-1-ium. Molbank 2021, 2021 (3).

Articles Published in 2020


Park, G. K.;  Lee, J. H.;  Soriano, E.;  Choi, M.;  Bao, K.;  Katagiri, W.;  Kim, D.-Y.;  Paik, J.-H.;  Yun, S.-H.;  Frangioni, J. V.;  Clancy, T. E.;  Kashiwagi, S.;  Henary, M.; Choi, H. S., Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors. iScience 2020, 23 (4), 101006.

Ilina, K.;  MacCuaig, W. M.;  Laramie, M.;  Jeouty, J. N.;  McNally, L. R.; Henary, M., Squaraine Dyes: Molecular Design for Different Applications and Remaining Challenges. Bioconjugate Chemistry 2020, 31 (2), 194-213.

Yadav, Y.;  Owens, E.;  Nomura, S.;  Fukuda, T.;  Baek, Y.;  Kashiwagi, S.;  Choi, H. S.; Henary, M., Ultrabright and Serum-Stable Squaraine Dyes. Journal of Medicinal Chemistry 2020, 63 (17), 9436-9445.

Henary, M.;  Kananda, C.;  Rotolo, L.;  Savino, B.;  Owens, E. A.; Cravotto, G., Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry. RSC Advances 2020, 10 (24), 14170-14197.

Alsolmy, E.;  Abdelwahab, W. M.;  Martinez, V.;  Henary, M.; Patonay, G., Investigation of benzophenoxazine derivatives for the detection of latent fingerprints on porous surfaces. Journal of Photochemistry and Photobiology A: Chemistry 2020, 392, 112416.

Baart, V. M.;  Deken, M. M.;  Bordo, M. W.;  Bhairosingh, S. S.;  Salvatori, D. C. F.;  Hyun, H.;  Henary, M.;  Choi, H. S.;  Sier, C. F. M.;  Kuppen, P. J. K.;  van Scheltinga, A. G. T. T.;  March, T. L.;  Valentijn, A. R. P. M.;  Frangioni, J. V.; Vahrmeijer, A. L., Small Molecules for Multi-Wavelength Near-Infrared Fluorescent Mapping of Regional and Sentinel Lymph Nodes in Colorectal Cancer Staging. Front Oncol 2020, 10, 586112-586112.

Ahoulou, E. O.;  Drinkard, K. K.;  Basnet, K.;  St. Lorenz, A.;  Taratula, O.;  Henary, M.; Grant, K. B., DNA Photocleavage in the Near-Infrared Wavelength Range by 2-Quinolinium Dicarbocyanine Dyes. Molecules 2020, 25 (12).

Pitigala, P. K. D. D. P.;  Henary, M. M.; Perera, A. G. U., Effects of physical orientation of dye molecules and molecular orbitals on performance of solid-state dye sensitized solar cells. Materials Today: Proceedings 2020, 23, 43-48.

Articles Published in 2019


Basnet, K.;  Fatemipouya, T.;  St. Lorenz, A.;  Nguyen, M.;  Taratula, O.;  Henary, M.; Grant, K. B., Single photon DNA photocleavage at 830 nm by quinoline dicarbocyanine dyes. Chemical Communications 2019, 55 (84), 12667-12670.

Park, G. K.;  Lee, J. H.;  Levitz, A.;  El Fakhri, G.;  Hwang, N. S.;  Henary, M.; Choi, H. S., Lysosome-Targeted Bioprobes for Sequential Cell Tracking from Macroscopic to Microscopic Scales. Advanced Materials 2019, 31 (14), 1806216.

Hwang, D. W.;  Jo, M. J.;  Lee, J. H.;  Kang, H.;  Bao, K.;  Hu, S.;  Baek, Y.;  Moon, H. G.;  Lee, D. S.;  Kashiwagi, S.;  Henary, M.; Choi, H. S., Chemical Modulation of Bioengineered Exosomes for Tissue-Specific Biodistribution. Advanced Therapeutics 2019, 2 (11), 1900111.

Owens, E. A.;  Huynh, H. T.;  Stroeva, E. M.;  Barman, A.;  Ziabrev, K.;  Paul, A.;  Nguyen, S. V.;  Laramie, M.;  Hamelberg, D.;  Germann, M. W.;  Wilson, W. D.; Henary, M., Second Generation G-Quadruplex Stabilizing Trimethine Cyanines. Bioconjugate Chemistry 2019, 30 (10), 2647-2663.

Rohani, L.;  Makita, H.;  Levitz, A.;  Henary, M.; Hastings, G., Calculated vibrational properties of semiquinones in the A1 binding site in photosystem I. Biochimica et Biophysica Acta (BBA) – Bioenergetics 2019, 1860 (9), 699-707.

Articles Published in 2018


Levitz, A.;  Marmarchi, F.; Henary, M., Synthesis and Optical Properties of Near-Infrared meso-Phenyl-Substituted Symmetric Heptamethine Cyanine Dyes. Molecules 2018, 23 (2)

Laramie, M. D.;  Smith, M. K.;  Marmarchi, F.;  McNally, L. R.; Henary, M., Small Molecule Optoacoustic Contrast Agents: An Unexplored Avenue for Enhancing In Vivo Imaging. Molecules 2018, 23 (11).

Levitz, A.;  Marmarchi, F.; Henary, M., Introduction of various substitutions to the methine bridge of heptamethine cyanine dyes Via substituted dianil linkers. Photochemical & Photobiological Sciences 2018, 17 (10), 1409-1416.

Ma, X.;  Laramie, M.; Henary, M., Synthesis, optical properties and cytotoxicity of meso-heteroatom substituted IR-786 analogs. Bioorganic & Medicinal Chemistry Letters 2018, 28 (3), 509-514.

Su, H.;  Sun, C.-W.;  Liu, S.-M.;  He, X.;  Hu, H.;  Pawlik, K. M.;  Townes, T. M.;  Han, X.;  Klug, C. A.;  Henary, M.;  Chen, Y.;  Li, L.;  Zheng, Y. G.; Zhao, X., Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1. Blood Advances 2018, 2 (21), 2829-2836.

Articles Published in 2017


Yadav, Y.;  Levitz, A.;  Dharma, S.;  Aneja, R.; Henary, M., Effects of heterocyclic N-alkyl chain length on cancer cell uptake of near infrared heptamethine cyanine dyes. Dyes and Pigments 2017, 145, 307-314.

Wada, H.;  Hyun, H.;  Kang, H.;  Gravier, J.;  Henary, M.;  Bordo, M. W.;  Choi, H. S.; Frangioni, J. V., Intraoperative Near-Infrared Fluorescence Imaging of Thymus in Preclinical Models. The Annals of Thoracic Surgery 2017, 103 (4), 1132-1141.

Levitz, A.;  Holder, C.;  Soriano, E.; Henary, M., “Turn on” fluorescence response of monomethine cyanines caused by noncovalent binding to ct-DNA. Dyes and Pigments 2017, 145, 202-207.

Laramie, M. D.; Levitz, A.; Henary, M., Cyanine and Squaric Acid Metal Sensors. Sensors and Actuators B: Chemical 2017, 243, 1191-1204.

Dost, T. L.;  Gressel, M. T.; Henary, M., Synthesis and Optical Properties of Pentamethine Cyanine Dyes With Carboxylic Acid Moieties. Analytical Chemistry Insights 2017, 12, 1177390117711938.

Articles Published in 2016


Owens, E. A.;  Hyun, H.;  Dost, T. L.;  Lee, J. H.;  Park, G.;  Pham, D. H.;  Park, M. H.;  Choi, H. S.; Henary, M., Near-Infrared Illumination of Native Tissues for Image-Guided Surgery. Journal of Medicinal Chemistry 2016, 59 (11), 5311-5323.

Duleepa Pitigala, P. K. D.;  Henary, M. M.;  Owens, E. A.;  UnilPerera, A. G.; Tennakone, K., Excitonic photovoltaic effect in a cyanine dye molecular assembly electronically coupled to n- and p-type semiconductors. Journal of Photochemistry and Photobiology A: Chemistry 2016, 325, 39-44.

Martinez, V.; Henary, M., Nile Red and Nile Blue: Applications and Syntheses of Structural Analogues. Chemistry – A European Journal 2016, 22 (39), 13764-13782.

Hyun, H.;  Henary, M.;  Gao, T.;  Narayana, L.;  Owens, E. A.;  Lee, J. H.;  Park, G.;  Wada, H.;  Ashitate, Y.;  Frangioni, J. V.; Choi, H. S., 700-nm Zwitterionic Near-Infrared Fluorophores for Dual-Channel Image-Guided Surgery. Molecular Imaging and Biology 2016, 18 (1), 52-61.

Koo, H.;  Lee, J. H.;  Bao, K.;  Wu, Y.;  El Fakhri, G.;  Henary, M.;  Yun, S. H.; Choi, H. S., Site-Specific In Vivo Bioorthogonal Ligation via Chemical Modulation. Advanced Healthcare Materials 2016, 5 (19), 2510-2516.

Owens, E. A.;  Henary, M.;  El Fakhri, G.; Choi, H. S., Tissue-Specific Near-Infrared Fluorescence Imaging. Accounts of Chemical Research 2016, 49 (9), 1731-1740.

Soriano, E.;  Holder, C.;  Levitz, A.; Henary, M., Benz[c,d]indolium-containing Monomethine Cyanine Dyes: Synthesis and Photophysical Properties. Molecules 2016, 21 (1).

Articles Published in 2015


Owens, E.A., Hyun, H., Tawney, J.G., Choi, H., Henary, M. Correlating Molecular Character of NIR Imaging Agents with Tissue-specific Uptake. 2015 Journal of Medicinal Chemistry. Just Accepted.Picture5

Hyun, H.*, Owens, E.A.*, Wada, H., Levitz, A., Park, G., Park, M., H., Frangioni, J. V., Henary, M., Choi, H. S., Cartilage-Specific Near-Infrared Fluorophores for Biomedical Imaging, 2015 Accepted in  Angewandte Chemie. Top 5% of All Accepted Publications. *Co-First Authors.

Sloop, J.C., Holder, C., Henary, M. Selective Incorporation of Fluorine in Pyrazoles. 2015 Eur. JOC. In Press.

Owens, E.A., Lee, S., Choi, J., Henary, M.*, Choi, H*. NIR Fluorescent Small Molecules for Intraoperative Imaging. 2015 WIREs Nanomedicine and Nanobiotechnology. Early View. Invited Review

Mahoney, D.P., Owens, E.A., Fan, C., Hsiang,J-C., Henary, M., Dickson, R.M., Tailoring Cyanine Dark States for Improved Optically Modulated Fluorescence Recovery. 2015 J. Phys. Chem. B.

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Njiojob, C.*, Owens, E. A.*, Narayana, L.*, Hyun, H., Choi, H. S., Henary, M., Tailored Near-Infrared Contrast Agents for Image Guided Surgery. 2015 Journal of Medicinal Chemistry 58 (6), 2845-2854. *Co-First Authors

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Owens, E. A., Bruschi, N., Tawney, J. G., Henary, M. M. A Microwave-Assisted and Environmentally Benign Approach to the Synthesis of Near-Infrared Fluorescent Pentamethine Cyanine Dyes. 2015 Dyes and Pigments 113, 27-37.

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Hu, H., Owens, E. A., Yan, L., Levitz, A., Su, H., Zhao, X., Henary, M., Zheng, Y. G., Cyanine Inhibiting Agents for Protein Arginine Methyltransferase. 2015 Journal of Medicinal Chemistry

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Tawney, J.*, Owens, E. A.*, Henary, M., Facile, Stimulating and Visually Appealing pH-Based Instructional Demonstration 2015 Submitted to Journal of Chemical Education *Co-First Authors

Hyun, H., Park, M. H. Owens, E. A., Wada, H., Henary, M., Frangioni, J. V., and Choi, H. S. Parathyroid and Thyroid Gland Imaging using Fluorinated Polymethines. 2015 Nature Medicine, 21, 192-197.

Wada, H., Hyun, H., Vargas, C., Gravier, J., Park, G., Gioux, S., Fragnioni, J.V., Henary, M.*, Choi, H.S*. Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery. 2015 Theranostics 5 (1), 1-11.

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Henary, M.* Owens, E. A.,* Tawney, J. G., Creative Report Writing in Undergraduate Organic Chemistry Laboratory Inspires Non-Majors 2015 Journal of Chemical Education 92, 1, 90–95 . *Co-First Authors

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Articles Published in 2014


Ashitate, Y., Hyun, H., Kim, H.S., Lee, J.H., Henary, M., Frangioni, J.V., Choi, H. Simultaneous Mapping of Pan and Sentinel Lymph Nodes for Real-Time Image-Guided Surgery. 2014 Theranostics 4 (7), 693-700.

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Park, M.H., Hyun, H., Ashitate, Y., Wada, H., Park , G., Lee, J.H., Njiojob, C., Henary, M. Frangioni, J.V., Choi, H. Prototype Nerve-Specific Near-Infrared Fluorophores. 2014 Theranostics 4 (8), 823-833.

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Hyun, H., Wada, H., Bao, K., Gravier, J., Yadav, Y., Laramie, M., Henary, M. Frangioni, J.V., Choi, H.S. Phosphonated Near-Infrared Fluorophores for Biomedical Imaging of Bone. 2014 Angew Chem Int Ed 53 (40), 10668-10672.

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Henary, M., Dost, T.A., Owens, E.A., Punganuru, S.R. Combining BACE1 Inhibition with Metal Chelation as Possible Therapy for Alzheimer’s Disease. 2014 Frontiers in Drug Design & Discovery 6 (19) 547-565. DOI: 10.2174/9781608058228114060013. Invited Book Chapter

Salim, M. M.*, Owens, E. A.*, Gao, T.*, Lee, J. H., Hyun, H., Choi, H. S., Henary, M. Hydroxylated Near-infrared BODIPY Fluorophores as Intracellular pH Sensors. 2014 Analyst, *Co-First Authors

Graphical abstract: Hydroxylated near-infrared BODIPY fluorophores as intracellular pH sensors

Henary, M., Narayana, L., Ahad, S., Sharma, V., Owens, E. A., Yadav, Y., Nagaraju, M., Hamelberg, D., Tandon, V., Panda, D., Aneja, R. Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity 2014 92, 2, 192-205 Biochemical Pharmacology

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Yadav, Y., Owens, E.A., Sharma, V., Aneja, R. Synthesis and evaluation of antiproliferative activity of a novel series of hydroxychavicol analogs 2014 European Journal of Medicinal Chemistry 75 1-10.

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Levitz, A., Ladani, S.T., Hamelberg, D., Henary, M. Synthesis and Effect of Heterocycle Modification on the Spectroscopic Properties of Series of Unsymmetrical Trimethine Cyanine Dyes 2014 Dyes and Pigments 105, 238-249. PMCID: In Process.

Owens, E. A., Tawney, J. G., Henary, M. M. 2-{(E)-2-[(3E)-2-Chloro-3-{(2E)-2-[1,1-dimethyl-3-(3-phenylpropyl)-1,3-dihydro-2H-benzo[e]indol-2-ylidene]-ethylidene}cyclohex-1-en-1-yl]ethenyl}-1,1-dimethyl-3-(3-phenylpropyl)-1H benzo[e]indolium Iodide. Molbank 2014

Mapp, C. T.*, Owens, E. A.* Henary, M,Grant, K. B.. Oxidative cleavage of DNA by pentamethine carbocyanine dyes irradiated with long wavelength visible light. Bioorganic & Med. Chem. Let., 2014, 24, 1, 214-9. *Co-First Authors

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Chapman, G., Solomon, I., Patonay G.*, Henary, M.* Synthesis and pH-Dependent Spectroscopic Behavior of 2,4,6-Trisubstituted Pyridine Derivatives 2014 J. Heterocycl. Chem. In press.

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Articles Published in 2013


Nanjunda, R., Owens, E. A., Mickelson, L., Dost, T. L., Stroeva, E. M. E, Huynh, H. T., Germann, M. W., Henary, M. M., Wilson, W. D., Selective G-Quadruplex DNA Recognition by a New Class of Designed Cyanines Molecules 2013, 18(11), 13588-13607.

A. Levitz, M. Henary, Synthesis and applications of unsymmetrical carbocyanine dyes, Dyes and Pigments, 2013, 99, 3, 1107-1116.

Choi, H. S., Gibbs, S. L., Lee, J., H., Kim, S. H., Ashitate, Y., Liu, F., Hyun, H., Park G. L., Xie, Y., Bae, S., Henary, M., Frangioni, J. V. Targeted Zwitterionic Near-Infrared Fluorophores for Improved Optical Imaging Nature Biotechnology 2013, In Press

Owens, E.A., Hyun, H., Kim, S. H., Lee, J. H., Park, G., Ashitate, Y., Choi, J., Hong, G. H., Alyabyev, S., Lee, S. J., Khang, G., Henary, M.*, Choi, H. S.* Highly charged cyanine fluorophores for trafficking scaffold degradation Biomedical Materials. 2013

Kim, S. H., Park, G., Lee, J. H., Ashitate, Y., Choi, J., Hong, G. H., Owens, E.A., Henary, M.,*Choi, H.S.* “Near-infrared lipophilic fluorophores for tracing tissue growth”. Biomedical Materials. 2013.

Soriano, E., Outler, L., Owens, E.A., Henary, M.* Synthesis of Asymmetric Monomethine Cyanine Dyes with Red-Shifted Optical Properties. J. Heterocycl. Chem. 2013; in press.

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Henary, M.; Paranjpe, S.; Owens, E.A. Substituted benzothiazoles – synthesis and medicinal characteristics . Heterocycl. Commun. 2013. Invited Review

Henary, M.; Paranjpe, S.; Owens, E.A. Synthesis and application of benzothiazole containing cyanine dyes. Heterocycl. Commun. 2013, 19. Invited Review

Articles Published In 2012


Henary, M.,* Pannu, V., Owens, E. A., Aneja, R.* “Near infrared active heptacyanine dyes with unique cancer-imaging and cytotoxic properties” Bioorg. & Med. Chem. Let. 2012, 22 (2) 1242-1246.Full-size image (27 K)

Nanjunda, R., Owens, E. A., Mickelson, L., Alyabyev, S. Kilpatrick, N., Wang, S.,Henary, M.,* Wilson, D. W.* “Halogenated pentamethine cyanine dyes exhibiting high fidelity for G-quadruplex DNA” Bioorg. & Med. Chem. 2012, 20 (24) 7002-7011.

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Beckford, G., Owens, E., Henary, M., Patonay, G. “The solvatochromic effects of side chain substitution on the binding interaction of novel tricarbocyanine dyes with human serum albumin” Talanta 2012, 92, 45-52.

Ashitate, Y., Kim, S. H., Tanaka, E., Henary, M., Choi, H.S. Frangioni, J. V., Flaumenhaft, R. Two-Wavelength Near-Infrared Fluorescence for the Quantitation of Drug Anti-Platelet Effects in Large Animal Model Systems. Journal of Vascular Surgery 2012, 56, 171-180.

Hyun, H., Bordoa, M., W., Nasr, K., Feitha, D., Lee, J. H., Kim, S. H., Ashitatea, Y., Moffitt L. A., Rosenberg, M., Henary, M., Choi, H., Frangioni, J. V. cGMP-Compatible preparative scale synthesis of near-infrared fluorophores Contrast Media Mol. Imaging 2012, 7(6), 516–524.

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Halder, S., Owens, E. A., Feng, Y., Yang, Y., Xie, Y., Tu, Y., Henary, M.,* Zheng, Y. G.*“Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents” Eur. J. of Med. Chem. 2012, 54, 647-59.

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Lee, J. H, Hyun, H, Cross, J. C., Henary, M., Nasr, K., Okerokoun, R., Choi, H, S., Frangioni, J. V. Rapid and Facile Microwave-Assisted Surface Chemistry for Functionalized Microarray Slides. Adv. Funct. Mater., 2012, 22 (4) 872-878.

Selected Peer Reviewed Publications (Previous Years)


Choi, H, S., Nasr, K., Alyabyev, S., Feith, D., Lee, J. H., Kim, S., H., Ashitate, Y., Hyun, H., Patonay, G., Strekowski, L., Henary, M., Frangioni, J. V., Zwitterionic Near-Infrared Fluorophores and their In Vivo Fate Angew. Chem. Int. Ed. 2011. 50 (28) 6258-6263.

Mishra, R. C., Karna, P., Gundala, S. R., Pannu, V., Stanton, R. A., Gupta, K. K., Robinson, M. H., Lopus, M., Wilson, L., Henary, M., Aneja, R. Second generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluation. Biochem Pharmacol. 2011, 82 (2), 110-21

Chapman G., Henary M., Patonay G.” The Effect of Varying Short-Chain Alkyl Substitution on the Molar Absorptivity and Quantum Yield of Cyanine Dyes” 2011, Journal of Analytical Insights.

Shi, Ch., Yang, X., Tong, Haiyen Z., Zhau, E., Wang, R., Cheng, J., Zayzafoon, M., Yang, V., Cheng, T., Henary, M., Strekowski, L., Chung, L. K. W. ”Dual imaging and  targeting with heptamethine cyanine near infrared fluorescence  dyes for cancer detection and treatment” J. Am. Assoc. Can. Res. 2010, 16(10)  2833-2844.

Chaudhry, A. F., Verma, M. M., Morgan, T., Henary, M. M., Siegel, N., Hales, J.  M., Perry, J. W., Fahrni, C. J., “Kinetically Controlled Photoinduced Electron Transfer Switching in Cu(I)-Responsive Fluorescent Probes”J. Am. Chem. Soc. 2010, 132 (2), 737-747.

Henary M., Mojzych, M., Say M., Strekowski, L. “Functionalization of Benz[c,d]indoleSystem for the Synthesis of Visible and Near-Infrared Dyes” J. Heterocycl. Chem. 2009, 46 (1), 84-87.

E. Wolinska, M. Henary, E. Paliakov, and L. Strekowski, “Near-Infrared Bisindolium heptamethine cyanine Dyes with a Spacer Derived from Oligo(ethyleneglycol),” J. Heterocycl. Chem. 2009, 46(5) 925-930.

Hyeran, L., Mikhail B. Y., Henary, M., Strekowski, L., Achilefu, S. “Fluorescence Lifetime Properties of near-infrared cyanine dyes in relation to their structures” J. Photochem. And Photobiology A 2008, 200 (2-3), 438-444.

Sumalekshmy, S., Henary, M., Wu, Y., Lawson, P., Schmidt, K., Brédas, J. L., Siegel, N., Perry, J. P., Fahrni, J. C. “Design of Emission Ratiometric Metal-Ion Sensors with Enhanced Two-Photon Cross-Section and Brightness” J. Am. Chem. Soc., 2007 129  (39)11888-11889.

Henary, M., Wu, Y., Fahrni, C. J. “Excited State Intramolecular Protontransfer in 2-(2’-Sulfona-midophenyl) benzimidazole Derivatives: The Effect of Donor and Acceptor Substituents” J. Org. Chem. 2007 72, 4784-4797.

Patonay, G., Strekowski, L., Kim, J. S., Henary, M. “The Increasing Role of NIR Fluorescence Spectroscopy in Bioanalytical Chemistry NIR News 2007, 18, 3.

Wu, Y., Lawson, P., Henary, M., Schmidt, K., Brédas, J. L., Fahrni, C. J. “Excited State Intramolecular Proton Transfer in 2-(2’-Arylsulfonamidophenyl) Benzimidazole Derivatives: Insights into the Origin of Donor Substituent-Induced Emission Energy Shifts” J. Phys. Chem. A, 2007, 111 (21), 4584-4595 .

Book Chapters Pre-2012


Henary, M., Mojzych, M. “Stability and Reactivity of Polymethine Dyes in Solution”, Topics in Heterocyclic, Editor Strekowski, Springer-Verlag Berlin Heidelberg 2008; Vol. 14, PP 221-238.

Mojzych, M., Henary, M. “Synthesis of Polymethine Dyes, Topics in Heterocyclic, Editor Strekowski, Springer-Verlag Berlin Heidelberg 2008; Vol. 14, PP 1-9.

Kim, J., Watson, A., Henary, M. and Patonay, G. “Near-Infrared Cyanine Dye Protein Interactions”, Topics in Heterocyclic, Editor Strekowski, Springer-Verlag Berlin Heidelberg 2008; Vol. 14, PP 31-39.

Strekowski, L, Saczewski, J., Henary, M. “Polycyclic Systems – Three Heterocyclic Rings Fused (6:5:6),” in Comprehensive Heterocyclic Chemistry III, Elsevier: Oxford, 2008; Vol. 12, pp 975-1006.

Strekowski, L., Henary, M., M. Mojzych, “Polycyclic Systems – Three  Heterocyclic Rings Fused (6:6:6) in Comprehensive Heterocyclic Chemistry III, Elsevier: Oxford, 2008; Vol. 12, pp 1007-1036.

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