Publications

Articles Published in 2015


Owens, E.A., Hyun, H., Tawney, J.G., Choi, H., Henary, M. Correlating Molecular Character of NIR Imaging Agents with Tissue-specific Uptake. 2015 Journal of Medicinal Chemistry. Just Accepted.Picture5

Hyun, H.*, Owens, E.A.*, Wada, H., Levitz, A., Park, G., Park, M., H., Frangioni, J. V., Henary, M., Choi, H. S., Cartilage-Specific Near-Infrared Fluorophores for Biomedical Imaging, 2015 Accepted in  Angewandte Chemie. Top 5% of All Accepted Publications. *Co-First Authors.

Sloop, J.C., Holder, C., Henary, M. Selective Incorporation of Fluorine in Pyrazoles. 2015 Eur. JOC. In Press.

Owens, E.A., Lee, S., Choi, J., Henary, M.*, Choi, H*. NIR Fluorescent Small Molecules for Intraoperative Imaging. 2015 WIREs Nanomedicine and Nanobiotechnology. Early View. Invited Review

Mahoney, D.P., Owens, E.A., Fan, C., Hsiang,J-C., Henary, M., Dickson, R.M., Tailoring Cyanine Dark States for Improved Optically Modulated Fluorescence Recovery. 2015 J. Phys. Chem. B.

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Njiojob, C.*, Owens, E. A.*, Narayana, L.*, Hyun, H., Choi, H. S., Henary, M., Tailored Near-Infrared Contrast Agents for Image Guided Surgery. 2015 Journal of Medicinal Chemistry 58 (6), 2845-2854. *Co-First Authors

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Owens, E. A., Bruschi, N., Tawney, J. G., Henary, M. M. A Microwave-Assisted and Environmentally Benign Approach to the Synthesis of Near-Infrared Fluorescent Pentamethine Cyanine Dyes. 2015 Dyes and Pigments 113, 27-37.

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Hu, H., Owens, E. A., Yan, L., Levitz, A., Su, H., Zhao, X., Henary, M., Zheng, Y. G., Cyanine Inhibiting Agents for Protein Arginine Methyltransferase. 2015 Journal of Medicinal Chemistry

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Tawney, J.*, Owens, E. A.*, Henary, M., Facile, Stimulating and Visually Appealing pH-Based Instructional Demonstration 2015 Submitted to Journal of Chemical Education *Co-First Authors

Hyun, H., Park, M. H. Owens, E. A., Wada, H., Henary, M., Frangioni, J. V., and Choi, H. S. Parathyroid and Thyroid Gland Imaging using Fluorinated Polymethines. 2015 Nature Medicine, 21, 192-197.

Wada, H., Hyun, H., Vargas, C., Gravier, J., Park, G., Gioux, S., Fragnioni, J.V., Henary, M.*, Choi, H.S*. Pancreas-targeted NIR fluorophores for dual-channel image-guided abdominal surgery. 2015 Theranostics 5 (1), 1-11.

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Henary, M.* Owens, E. A.,* Tawney, J. G., Creative Report Writing in Undergraduate Organic Chemistry Laboratory Inspires Non-Majors 2015 Journal of Chemical Education 92, 1, 90–95 . *Co-First Authors

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Articles Published in 2014


Ashitate, Y., Hyun, H., Kim, H.S., Lee, J.H., Henary, M., Frangioni, J.V., Choi, H. Simultaneous Mapping of Pan and Sentinel Lymph Nodes for Real-Time Image-Guided Surgery. 2014 Theranostics 4 (7), 693-700.

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Park, M.H., Hyun, H., Ashitate, Y., Wada, H., Park , G., Lee, J.H., Njiojob, C., Henary, M. Frangioni, J.V., Choi, H. Prototype Nerve-Specific Near-Infrared Fluorophores. 2014 Theranostics 4 (8), 823-833.

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Hyun, H., Wada, H., Bao, K., Gravier, J., Yadav, Y., Laramie, M., Henary, M. Frangioni, J.V., Choi, H.S. Phosphonated Near-Infrared Fluorophores for Biomedical Imaging of Bone. 2014 Angew Chem Int Ed 53 (40), 10668-10672.

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Henary, M., Dost, T.A., Owens, E.A., Punganuru, S.R. Combining BACE1 Inhibition with Metal Chelation as Possible Therapy for Alzheimer’s Disease. 2014 Frontiers in Drug Design & Discovery 6 (19) 547-565. DOI: 10.2174/9781608058228114060013. Invited Book Chapter

Salim, M. M.*, Owens, E. A.*, Gao, T.*, Lee, J. H., Hyun, H., Choi, H. S., Henary, M. Hydroxylated Near-infrared BODIPY Fluorophores as Intracellular pH Sensors. 2014 Analyst, *Co-First Authors

Graphical abstract: Hydroxylated near-infrared BODIPY fluorophores as intracellular pH sensors

Henary, M., Narayana, L., Ahad, S., Sharma, V., Owens, E. A., Yadav, Y., Nagaraju, M., Hamelberg, D., Tandon, V., Panda, D., Aneja, R. Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity 2014 92, 2, 192-205 Biochemical Pharmacology

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Yadav, Y., Owens, E.A., Sharma, V., Aneja, R. Synthesis and evaluation of antiproliferative activity of a novel series of hydroxychavicol analogs 2014 European Journal of Medicinal Chemistry 75 1-10.

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Levitz, A., Ladani, S.T., Hamelberg, D., Henary, M. Synthesis and Effect of Heterocycle Modification on the Spectroscopic Properties of Series of Unsymmetrical Trimethine Cyanine Dyes 2014 Dyes and Pigments 105, 238-249. PMCID: In Process.

Owens, E. A., Tawney, J. G., Henary, M. M. 2-{(E)-2-[(3E)-2-Chloro-3-{(2E)-2-[1,1-dimethyl-3-(3-phenylpropyl)-1,3-dihydro-2H-benzo[e]indol-2-ylidene]-ethylidene}cyclohex-1-en-1-yl]ethenyl}-1,1-dimethyl-3-(3-phenylpropyl)-1H benzo[e]indolium Iodide. Molbank 2014

Mapp, C. T.*, Owens, E. A.* Henary, M,Grant, K. B.. Oxidative cleavage of DNA by pentamethine carbocyanine dyes irradiated with long wavelength visible light. Bioorganic & Med. Chem. Let., 2014, 24, 1, 214-9. *Co-First Authors

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Chapman, G., Solomon, I., Patonay G.*, Henary, M.* Synthesis and pH-Dependent Spectroscopic Behavior of 2,4,6-Trisubstituted Pyridine Derivatives 2014 J. Heterocycl. Chem. In press.

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Articles Published in 2013


Nanjunda, R., Owens, E. A., Mickelson, L., Dost, T. L., Stroeva, E. M. E, Huynh, H. T., Germann, M. W., Henary, M. M., Wilson, W. D., Selective G-Quadruplex DNA Recognition by a New Class of Designed Cyanines Molecules 2013, 18(11), 13588-13607.

A. Levitz, M. Henary, Synthesis and applications of unsymmetrical carbocyanine dyes, Dyes and Pigments, 2013, 99, 3, 1107-1116.

Choi, H. S., Gibbs, S. L., Lee, J., H., Kim, S. H., Ashitate, Y., Liu, F., Hyun, H., Park G. L., Xie, Y., Bae, S., Henary, M., Frangioni, J. V. Targeted Zwitterionic Near-Infrared Fluorophores for Improved Optical Imaging Nature Biotechnology 2013, In Press

Owens, E.A., Hyun, H., Kim, S. H., Lee, J. H., Park, G., Ashitate, Y., Choi, J., Hong, G. H., Alyabyev, S., Lee, S. J., Khang, G., Henary, M.*, Choi, H. S.* Highly charged cyanine fluorophores for trafficking scaffold degradation Biomedical Materials. 2013

Kim, S. H., Park, G., Lee, J. H., Ashitate, Y., Choi, J., Hong, G. H., Owens, E.A., Henary, M.,*Choi, H.S.* “Near-infrared lipophilic fluorophores for tracing tissue growth”. Biomedical Materials. 2013.

Soriano, E., Outler, L., Owens, E.A., Henary, M.* Synthesis of Asymmetric Monomethine Cyanine Dyes with Red-Shifted Optical Properties. J. Heterocycl. Chem. 2013; in press.

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Henary, M.; Paranjpe, S.; Owens, E.A. Substituted benzothiazoles – synthesis and medicinal characteristics . Heterocycl. Commun. 2013. Invited Review

Henary, M.; Paranjpe, S.; Owens, E.A. Synthesis and application of benzothiazole containing cyanine dyes. Heterocycl. Commun. 2013, 19. Invited Review

Articles Published In 2012


Henary, M.,* Pannu, V., Owens, E. A., Aneja, R.* “Near infrared active heptacyanine dyes with unique cancer-imaging and cytotoxic properties” Bioorg. & Med. Chem. Let. 2012, 22 (2) 1242-1246.Full-size image (27 K)

Nanjunda, R., Owens, E. A., Mickelson, L., Alyabyev, S. Kilpatrick, N., Wang, S.,Henary, M.,* Wilson, D. W.* “Halogenated pentamethine cyanine dyes exhibiting high fidelity for G-quadruplex DNA” Bioorg. & Med. Chem. 2012, 20 (24) 7002-7011.

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Beckford, G., Owens, E., Henary, M., Patonay, G. “The solvatochromic effects of side chain substitution on the binding interaction of novel tricarbocyanine dyes with human serum albumin” Talanta 2012, 92, 45-52.

Ashitate, Y., Kim, S. H., Tanaka, E., Henary, M., Choi, H.S. Frangioni, J. V., Flaumenhaft, R. Two-Wavelength Near-Infrared Fluorescence for the Quantitation of Drug Anti-Platelet Effects in Large Animal Model Systems. Journal of Vascular Surgery 2012, 56, 171-180.

Hyun, H., Bordoa, M., W., Nasr, K., Feitha, D., Lee, J. H., Kim, S. H., Ashitatea, Y., Moffitt L. A., Rosenberg, M., Henary, M., Choi, H., Frangioni, J. V. cGMP-Compatible preparative scale synthesis of near-infrared fluorophores Contrast Media Mol. Imaging 2012, 7(6), 516–524.

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Halder, S., Owens, E. A., Feng, Y., Yang, Y., Xie, Y., Tu, Y., Henary, M.,* Zheng, Y. G.*“Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents” Eur. J. of Med. Chem. 2012, 54, 647-59.

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Lee, J. H, Hyun, H, Cross, J. C., Henary, M., Nasr, K., Okerokoun, R., Choi, H, S., Frangioni, J. V. Rapid and Facile Microwave-Assisted Surface Chemistry for Functionalized Microarray Slides. Adv. Funct. Mater., 2012, 22 (4) 872-878.

Selected Peer Reviewed Publications (Previous Years)


Choi, H, S., Nasr, K., Alyabyev, S., Feith, D., Lee, J. H., Kim, S., H., Ashitate, Y., Hyun, H., Patonay, G., Strekowski, L., Henary, M., Frangioni, J. V., Zwitterionic Near-Infrared Fluorophores and their In Vivo Fate Angew. Chem. Int. Ed. 2011. 50 (28) 6258-6263.

Mishra, R. C., Karna, P., Gundala, S. R., Pannu, V., Stanton, R. A., Gupta, K. K., Robinson, M. H., Lopus, M., Wilson, L., Henary, M., Aneja, R. Second generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluation. Biochem Pharmacol. 2011, 82 (2), 110-21

Chapman G., Henary M., Patonay G.” The Effect of Varying Short-Chain Alkyl Substitution on the Molar Absorptivity and Quantum Yield of Cyanine Dyes” 2011, Journal of Analytical Insights.

Shi, Ch., Yang, X., Tong, Haiyen Z., Zhau, E., Wang, R., Cheng, J., Zayzafoon, M., Yang, V., Cheng, T., Henary, M., Strekowski, L., Chung, L. K. W. ”Dual imaging and  targeting with heptamethine cyanine near infrared fluorescence  dyes for cancer detection and treatment” J. Am. Assoc. Can. Res. 2010, 16(10)  2833-2844.

Chaudhry, A. F., Verma, M. M., Morgan, T., Henary, M. M., Siegel, N., Hales, J.  M., Perry, J. W., Fahrni, C. J., “Kinetically Controlled Photoinduced Electron Transfer Switching in Cu(I)-Responsive Fluorescent Probes”J. Am. Chem. Soc. 2010, 132 (2), 737-747.

Henary M., Mojzych, M., Say M., Strekowski, L. “Functionalization of Benz[c,d]indoleSystem for the Synthesis of Visible and Near-Infrared Dyes” J. Heterocycl. Chem. 2009, 46 (1), 84-87.

E. Wolinska, M. Henary, E. Paliakov, and L. Strekowski, “Near-Infrared Bisindolium heptamethine cyanine Dyes with a Spacer Derived from Oligo(ethyleneglycol),” J. Heterocycl. Chem. 2009, 46(5) 925-930.

Hyeran, L., Mikhail B. Y., Henary, M., Strekowski, L., Achilefu, S. “Fluorescence Lifetime Properties of near-infrared cyanine dyes in relation to their structures” J. Photochem. And Photobiology A 2008, 200 (2-3), 438-444.

Sumalekshmy, S., Henary, M., Wu, Y., Lawson, P., Schmidt, K., Brédas, J. L., Siegel, N., Perry, J. P., Fahrni, J. C. “Design of Emission Ratiometric Metal-Ion Sensors with Enhanced Two-Photon Cross-Section and Brightness” J. Am. Chem. Soc., 2007 129  (39)11888-11889.

Henary, M., Wu, Y., Fahrni, C. J. “Excited State Intramolecular Protontransfer in 2-(2’-Sulfona-midophenyl) benzimidazole Derivatives: The Effect of Donor and Acceptor Substituents” J. Org. Chem. 2007 72, 4784-4797.

Patonay, G., Strekowski, L., Kim, J. S., Henary, M. “The Increasing Role of NIR Fluorescence Spectroscopy in Bioanalytical Chemistry NIR News 2007, 18, 3.

Wu, Y., Lawson, P., Henary, M., Schmidt, K., Brédas, J. L., Fahrni, C. J. “Excited State Intramolecular Proton Transfer in 2-(2’-Arylsulfonamidophenyl) Benzimidazole Derivatives: Insights into the Origin of Donor Substituent-Induced Emission Energy Shifts” J. Phys. Chem. A, 2007, 111 (21), 4584-4595 .

Book Chapters Pre-2012


Henary, M., Mojzych, M. “Stability and Reactivity of Polymethine Dyes in Solution”, Topics in Heterocyclic, Editor Strekowski, Springer-Verlag Berlin Heidelberg 2008; Vol. 14, PP 221-238.

Mojzych, M., Henary, M. “Synthesis of Polymethine Dyes, Topics in Heterocyclic, Editor Strekowski, Springer-Verlag Berlin Heidelberg 2008; Vol. 14, PP 1-9.

Kim, J., Watson, A., Henary, M. and Patonay, G. “Near-Infrared Cyanine Dye Protein Interactions”, Topics in Heterocyclic, Editor Strekowski, Springer-Verlag Berlin Heidelberg 2008; Vol. 14, PP 31-39.

Strekowski, L, Saczewski, J., Henary, M. “Polycyclic Systems – Three Heterocyclic Rings Fused (6:5:6),” in Comprehensive Heterocyclic Chemistry III, Elsevier: Oxford, 2008; Vol. 12, pp 975-1006.

Strekowski, L., Henary, M., M. Mojzych, “Polycyclic Systems – Three  Heterocyclic Rings Fused (6:6:6) in Comprehensive Heterocyclic Chemistry III, Elsevier: Oxford, 2008; Vol. 12, pp 1007-1036.

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