Cell Death Atlas

The “Cell Death Atlas” is a project started several years ago by Todd H. Ahern & Nancy G. Forger to map naturally occurring cell death in the mouse brain during the late prenatal and early postnatal period. The atlas comprises scanned microscope slides of ~275 mouse brains of both sexes, age embryonic day 17 through postnatal day 11. All brains have been frozen sectioned, immunohistochemically stained for the cell death marker activated caspase 3 (AC3), and counterstained with thionin.

The first part of the atlas covers postnatal day 1 through 11 and is the subject of a publication (Ahern et al., 2013). We have recently expanded the atlas to include earlier time points [embryonic day (E) 17, 18, and 19, and postnatal day 0].

A sample “page” from the atlas is shown below. Each image can be zoomed up to 400X equivalent magnification.

Page from Cell Death Atlas

Investigators interested getting access to atlas files should contact Nancy Forger or Todd Ahern.

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